Browsing by Author "Yelekçi, K."
Now showing items 1-4 of 4
-
Computational Chemistry and Molecular Modeling of Reversible MAO Inhibitors
Yelekçi, K.; Erdem, S.S. (Humana Press Inc., 2023)Proper elucidation of drug-target interaction is one of the most significant steps at the early stages of the drug development research. Computer-aided drug design tools have substantial contribution to this stage. In this ... -
Investigation of synthesis, molecular modelling and monoaminoxidase inhibitor activity of a new 2-pyrazoline compound
Evranos-Aksöz, B.; Uçar, G.; Yelekçi, K. (Refik Saydam National Public Health Agency (RSNPHA), 2018)Objective: Isoforms of monoamine oxidase (MAO-A and -B) which are responsible for the degradation of neuromediators are involved in many diseases, and MAO inhibitors are used for the treatment of some diseases such as ... -
Molecular modeling studies of some phytoligands from Ficus sycomorus fraction as potential inhibitors of cytochrome CYP6P3 enzyme of Anopheles coluzzii
Babandi, A.; Anosike, C.A.; Ezeanyika, L.U.S.; Yelekçi, K.; Uba, A.I. (University of Jordan,Deanship of Scientific Research, 2022)The major obstacle in controlling malaria is the mosquito’s resistance to insecticides, including pyrethroids. The resistance is mainly due to the over-expression of detoxification enzymes such as cytochromes. Insecticides ... -
Novel azole-urea hybrids as VEGFR-2 inhibitors: Synthesis, in vitro antiproliferative evaluation and in silico studies
Shirzad, M.M.; Kulabaş, N.; Erdoğan, Ö.; Çevik, Ö.; Dere, D.; Yelekçi, K.; Danış, Ö. (Elsevier B.V., 2023)The vascular endothelial growth factor receptor-2 (VEGFR-2) is a receptor tyrosine kinase known to be abnormally expressed in various malignant tumors, including breast cancer, and is considered one of the most important ...